Pathogenesis and management of postprandial hyperglycemia: role of incretin-based therapies

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Pathogenesis and management of postprandial hyperglycemia: role of incretin-based therapies

Postprandial plasma glucose concentrations are an important contributor to glycemic control. There is evidence suggesting that postprandial hyperglycemia may be an independent risk factor for cardiovascular disease. Glucagon-like peptide-1 (GLP-1) receptor agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors are antidiabetic agents that predominantly reduce postprandial plasma glucose levels....

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INTRODUCTION (BY M.A.N.) — Incretin mimetics and inhibitors of the protease dipeptidyl peptidase (DPP)-4 are new classes of antidiabetic agents first introduced in the years 2005 (exenatide) and 2007 (sitagliptin), respectively. Both use the antidiabetic properties of the incretin hormone, glucagon-like peptide (GLP)-1 (1). This gut-derived peptide hormone not only augments glucose-induced insu...

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ژورنال

عنوان ژورنال: International Journal of General Medicine

سال: 2013

ISSN: 1178-7074

DOI: 10.2147/ijgm.s51665